Fractional Laser Enhances Delivery of Liposomes

Fractional Laser Enhances Delivery of Hydrophilic Peptides

Peptides can have a beneficial effect on skin health, but typically offer poor transdermal penetration due to their hydrophilic nature. In an effort to improve penetration and cellular uptake, researchers Takahiro Fujimoto, MD, PhD, et al, irradiated the skin of Yucatan micropigs using a CO2 fractional laser at varying energy levels prior to application of a hydrophilic peptide drugs 5-carboxyfluorescein (CF) and fluorescein isothiocyanate-conjugated ovalbumin (OVA-FITC) encapsulated in liposomes.

Chain Reaction

The efficacy of peptides is well supported by clinical research, but how does this evidence translate to cosmeceutical formulations?
Chain Reaction

Skin proteins—keratin, melanin, collagen, elastin, gelatin—give structure to cells, transmit signals from the cell surface to the organelles and mitochondria, and control the regeneration of tissues. Peptides—which are protein fragments—are popular active ingredients in skincare formulations, where they are used to affect the behavior of skin cells.

Skincare Product: ChronoPeptideA

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Rhonda Allison Cosmeceuticals’ ChronoPeptideA stimulates collagen synthesis and exfoliation to tone and firm the skin. The formula features encapsulated retinaldehyde, plus anti-inflammatory and antioxidant ingredients mangosteen, B vitamin complex, cloud berry seed oil and ginseng root. ChronoPeptideA also helps to increase production of hyaluronic acid, activate epidermal and dermal cells to improve cell renewal, and protect and strengthen dry, irritated skin. Contact: 866.313.7546,