Soft Tissue Fillers

Delayed Adverse Events Following Larger Volume Injection of Voluma HA Filler


A retrospective review of 4,500 patients who received treatment with a smooth, cohesive 20-mg/mL hyaluronic acid filler, Juvéderm Voluma (HA-V), revealed a 0.98 percent rate of delayed adverse events (DAEs). The most common of which were swelling and nodule formation.

Shannon Humphrey, MD, et al, reviewed the charts from patients of two clinics who received HA-V between February 1, 2009 and February 28, 2018, in an effort to examine the occurrence of HA-V DAEs and identify patterns and characteristics.

FDA Approves Juvéderm VOLUMA XC For Midface Injection Via Cannula

New Allergan VOLUMA approval

Allergan has received U.S. Food and Drug Administration (FDA) approval for the use of its hyaluronic acid gel dermal filler Juvéderm VOLUMA XC with a TSK STERiGLIDE cannula for cheek augmentation to correct age-related volume deficit in the midface in adults over 21. The TSK STERiGLIDE has a unique design compared to other cannulas currently available. It offers a patented tapered tip design for easier pilot entry as well as a near-tip delivery port for more precise product placement.

Global Injections

Full-face rejuvenation with injectables offers high patient satisfaction, but requires advanced training and an awareness of risk factors.
MedEsthetics July/August 2018

When medical aesthetic practices first began to use the term “Liquid Facelift” to describe the use of fillers and botulinum toxins for facial rejuvenation, there was some discomfort in the industry. Many practitioners were wary of suggesting that patients could achieve results comparable to a facelift nonsurgically, and the outcomes were not always ideal. But with experience, new indications and improved techniques, outcomes have improved significantly.

Nodule Formation Following HA Filler Treatment

Lip Injections

Hyaluronic acid filler injections can cause persistent and recurring nodules that require combination therapies to clear. And products with a high degree of cross-linking may be more difficult to disintegrate with hyaluronidase. Authors Meredith L. Orseth MD, Nicole Lee MD, Omer Ibrahim MD, Kenneth A. Arndt MD, and Michael Kaminer MD, published two case studies of patients who experienced nodule formation after treatment with an HA filler (Journal of Drugs in Dermatology, May 2018).

Reducing Risks in Deep Filler Injections

Ultrasound for Deep Filler Injections

Researchers from Kobe University Graduate School of Medicine in Kobe, Japan, are advocating the use of two tools that may help reduce the risk of vascular embolism and skin necrosis following hyaluronic acid (HA) filler injections: ultrasound to help identify blood vessels during deep injections and 2-dimensional laser speckle flowgraphy (LSFG) to noninvasively measure blood flow to the skin.

A Single Entry Injection Method for Facial Volume Replacement

Soft tissue fillers are popular and effective tools for replacing lost volume in the face. The most common adverse event is bruising, particularly in patients who require injections to multiple areas. In an effort to reduce filler-related bruising, Hasan Galadari, MD, and Wolfgang Redka-Swoboda, MD, have developed a technique that allows practitioners to fill the cheek and tear trough through a single entry point injection site.

Newsmakers: Hydrating Fillers

Microdroplet injections of low-viscosity hyaluronic acid-based fillers are gaining fans around the globe.
The use of dermal fillers for hydration is making its way to the U.S.

Hydrating fillers—low-viscosity hyaluronic acid-based materials injected superficially throughout the face to improve skin tone—have become popular offerings outside of the U.S. and are finding their way onto aesthetic message boards and review sites, generating significant interest among U.S.-based consumers.

Outside the states, physicians have access to specifically formulated products, such as Juvéderm Hydrate, Restylane Vital and Restylane Vital Light, as well as robust marketing campaigns to educate consumers on these new hydrating treatments.