Soft Tissue Fillers

Global Injections

Full-face rejuvenation with injectables offers high patient satisfaction, but requires advanced training and an awareness of risk factors.
MedEsthetics July/August 2018

When medical aesthetic practices first began to use the term “Liquid Facelift” to describe the use of fillers and botulinum toxins for facial rejuvenation, there was some discomfort in the industry. Many practitioners were wary of suggesting that patients could achieve results comparable to a facelift nonsurgically, and the outcomes were not always ideal. But with experience, new indications and improved techniques, outcomes have improved significantly.

Nodule Formation Following HA Filler Treatment

Lip Injections

Hyaluronic acid filler injections can cause persistent and recurring nodules that require combination therapies to clear. And products with a high degree of cross-linking may be more difficult to disintegrate with hyaluronidase. Authors Meredith L. Orseth MD, Nicole Lee MD, Omer Ibrahim MD, Kenneth A. Arndt MD, and Michael Kaminer MD, published two case studies of patients who experienced nodule formation after treatment with an HA filler (Journal of Drugs in Dermatology, May 2018).

Reducing Risks in Deep Filler Injections

Ultrasound for Deep Filler Injections

Researchers from Kobe University Graduate School of Medicine in Kobe, Japan, are advocating the use of two tools that may help reduce the risk of vascular embolism and skin necrosis following hyaluronic acid (HA) filler injections: ultrasound to help identify blood vessels during deep injections and 2-dimensional laser speckle flowgraphy (LSFG) to noninvasively measure blood flow to the skin.

A Single Entry Injection Method for Facial Volume Replacement

Soft tissue fillers are popular and effective tools for replacing lost volume in the face. The most common adverse event is bruising, particularly in patients who require injections to multiple areas. In an effort to reduce filler-related bruising, Hasan Galadari, MD, and Wolfgang Redka-Swoboda, MD, have developed a technique that allows practitioners to fill the cheek and tear trough through a single entry point injection site.

Newsmakers: Hydrating Fillers

Microdroplet injections of low-viscosity hyaluronic acid-based fillers are gaining fans around the globe.
The use of dermal fillers for hydration is making its way to the U.S.

Hydrating fillers—low-viscosity hyaluronic acid-based materials injected superficially throughout the face to improve skin tone—have become popular offerings outside of the U.S. and are finding their way onto aesthetic message boards and review sites, generating significant interest among U.S.-based consumers.

Outside the states, physicians have access to specifically formulated products, such as Juvéderm Hydrate, Restylane Vital and Restylane Vital Light, as well as robust marketing campaigns to educate consumers on these new hydrating treatments.

Starting in the Middle

New products and evolving techniques have put midface filling front and center for noninvasive facial rejuvenation.
Fillers for midface rejuvenation

The middle third of the face extends from the infraorbital rim to the upper lip and includes the zygomatic arch and maxilla. Age-related volume loss in this area is influenced by genetics, general health and dentition—among other factors—resulting in sagging fat pads, deepening nasolabial folds, and a host of hollows and wrinkles. Until the turn of the 21st century the only way to correct these problems was plastic surgery, a solution available to only a few.

Results From Phase 4 Clinical Studies of Restylane Refyne and Restylane Defyne Released

Phase 4 Clinical Study Results on Restylane Refyne and Defyne

Galderma has released the results from two Phase 4 clinical studies of Restylane Refyne and Restylane Defyne, the most recent U.S. additions to it Restylane family of soft tissue fillers. The Natural Expression study found that natural facial expression was maintained in 95% (60/63) of subjects (primary objective). The Dynamic Strain study found that 83% (25/30) of subjects had enhanced attractiveness, looked younger and maintained expression following injections of Restylane Refyne and Restylane Defyne.