Researchers Seek To Quantify Results of Fully Ablative vs. Fractionated CO2

CO2 Skin Resurfacing

Less downtime and a decreased risk of adverse events has made fractionated CO2 skin resurfacing a popular procedure in medical aesthetic practices. And serial skin samples show the procedure does offer skin rejuvenation benefits similar to traditional full-face CO2 resurfacing, say researchers from the Department of Dermatology at the University of Michigan, Ann Arbor, School of Medicine. The researchers, led by Jeffrey S. Orringer, MD, treated 34 adults with photoaged skin. Each patient was treated with a fully ablative CO2 laser and a fractionated CO2 laser at distinct sites. Serial skin samples were obtained to measure molecular response using real-time reverse transcriptase polymerase chain reaction technology and immunohistochemistry at baseline and following treatment.
The results, which were published in the journal of Dermatologic Surgery (October 2012), showed collagen induction following a single treatment with a fractionated CO2 laser was “40% to 50% as pronounced as that induced by fully ablative laser resurfacing.” The researchers concluded that “fundamental cutaneous responses that result from fully ablative and fractionated carbon dioxide laser resurfacing are similar but differ in magnitude and duration, with the fully ablative procedure inducing relatively greater changes including more pronounced collagen induction.”

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