Rapidly Polymerizing Collagen For Revolumization

RPC Pure-Collagen for Nasolabial Folds

Dermal fillers have moved from collagen-based to hyaluronic acid and now a new product is bringing collagen back in the form of a scaffold designed to stimulate fibroblast proliferation. In the October issue of Aesthetic Surgery, Christopher Inglefield, BSc, MBBS, FRCS and colleagues published the results of their prospective, multicenter, open-label study of RPC (Rapidly Polymerizing Collagen) Pure-Collagen from EternoGen Aesthetics. RPC Pure-Collagen is a sterile, nonpyrogenic, viscous, clear solution composed of pure porcine collagen, ethylenediamine tetraacetic acid (EDTA) and Mannitol that can be injected through a 30-gauge needle as a liquid. The liquid fibrilizes in situ forming a natural, open 3-dimensional collagen matrix for bio-dermal restoration.

The researchers treated 30 patients in the nasolabial fold and followed their outcomes for up 12 weeks after injection. A subset of patients was followed for up to nine months. The only adverse events were transient injection site reactions, which were mild or moderate in severity except for one case of severe bruising. There were no reports of hypersensitivity. The subjects all showed significant improvement from baseline based on both Merz Aesthetic Scale and Global Aesthetic Improvement Scale assessments.

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