Bakuchiol, a natural retinol alternative, is effective and well-tolerated in treating photodamage for patients with sensitive skin conditions, including atopic dermatitis, rosacea and cosmetic intolerance. Hemali Gunt, PhD, of Burt’s Bees and dermatologists Zoe Diana Draelos, MD, and Stanley B. Levy, MD, presented their findings during the American Academy of Dermatology Virtual VMX conference earlier this month.
Sixty females (aged 40-65) with sensitive skin resulting from eczema/atopic dermatitis, rosacea or cosmetic intolerance and mild to moderate signs of photoaging applied a topical cream containing bakuchiol daily for four weeks. Outcomes were based on both investigator and subject assessment 5-10 minutes after application and four weeks after commencing daily use of the product. The investigators also measured skin hydration and skin barrier function at baseline and after four weeks.
Treatment with the bakuchiol cream for four weeks showed statistically significant improvements in investigator-graded efficacy parameters, statistically significant improvements in subject-graded efficacy parameters, statistically significant increase in skin hydration, no significant changes in skin barrier function (indicating mildness of the product) and no significant tolerability issues.