When comparing the efficacy and tolerability of a fixed combination clindamycin (1.2%) and benzoyl peroxide (3.75%) aqueous gel for facial acne, researcher Julie C. Harper, MD, found that females treated with the gel experienced a greater reduction in acne lesions than males. In addition, a greater number of female subjects achieved a 2-grade reduction in acne severity. The multicenter, double-blind, vehicle-controlled, 12-week, 2-arm study (Journal of Drugs in Dermatology, April 2015) included 498 patients with moderate to severe acne vulgaris. The patients were randomized (1:1) to receive clindamycin phosphate 1.2%/ BP 3.75% gel or vehicle. The efficacy of clindamycin phosphate 1.2%/BP 3.75% gel was greater than vehicle (p > 0.001) in both genders.