A split-face study of 20 patients revealed that combination treatment with botulinum toxins and hyaluronic dermal fillers for forehead and glabella rhytides produced longer-lasting results than treatment with toxins alone. Meghan Dubina, MD, et al, of the Department of Dermatology, Northwestern University, Chicago, injected botulinum toxin alone on one side of the forehead/glabella and hyaluronic acid filler followed by botulinum toxin on the other side. Blinded ratings were obtained to assess the effectiveness of treatment for static and dynamic rhytides at two weeks, six weeks, three months and six months post treatment. Subjects performed a self-evaluation at the end of the study.
The results, which were published in the Journal of Cosmetic Dermatology (December 2013), revealed comparable efficacy in both areas with 100% of subjects experiencing an improvement from baseline at two, six and 12 weeks. At week 24, there was a greater reduction in static and dynamic wrinkles on the side that received combination treatment with toxins and HA fillers. The patient self-evaluations revealed a “nominal preference for combination treatment.”