MDRejuvena, a private company focused on professional physician-dispensed skin care, announced the publication of clinical results that demonstrated the ability of sodium copper chlorophyllin complex to repair photodamaged skin. Sodium copper chlorophyllin in a liposomal complex, branded as Phytochromatic MD Complex, is the primary ingredient in the MDRejuvena Rejuvaphyl line of skincare products.
The study, published in Clinical, Cosmetic and Investigational Dermatology (July 2016), demonstrated that the sodium copper chlorophyllin complex increases epidermal and dermal hyaluronic acid (HA), and precursors of collagen and elastin. (A previous study published in August 2015 found that sodium copper chlorophyllin complex is a strong inhibitor of hyaluronidase in vitro.)
In the most recent study, researchers obtained skin biopsy samples from the forearms of four healthy middle-aged women with signs of photoaged skin. Immunohistochemistry analysis for key biomarkers of aging skin was performed after each subject was treated with: a gel containing a liposomal dispersion of sodium copper chlorophyllin complex 0.05%; a positive control of tretinoin cream 0.025%; and an untreated negative control.
Both sodium copper chlorophyllin complex and retinoic acid treated had increases in all four biomarkers examined. (There was no statistical difference in results between sodium copper chlorophyllin and retinol treated sites.)
“The significant role sodium copper chlorophyllin can play in combatting the effects of skin aging is very exciting,” said Jason Lupton, MD, dermatologist and owner of Derm SD in San Diego. “Loss of hyaluronic acid in the skin with aging contributes to decreased tissue elasticity, loss of hydration and fine lines and wrinkles. Products that have activities to retain or enhance HA are extremely useful in repairing such aged skin.”