Medical Microneedling Affects Collagen and Elastin Gene Expression

“Noninvasive measurements and biopsy data showed changes in skin architecture and collagen/elastin gene expression suggesting skin rejuvenation, with new extracellular matrix production and muscle formation.”

Medical microneedling increases muscle in the dermis and expression of collagen and elastin
Medical microneedling increases muscle in the dermis and expression of collagen and elastin

Four sessions of medical microneedling increased epidermal density, dermal muscle and facial skin elasticity, according the results of a study by Jeffrey Kenkel, MD, et al, published in the Aesthetic Surgery Journal (February 28, 2021).

Thirty-five subjects between the ages of 44 and 65 years old with Fitzpatrick skin types I-IV underwent four monthly microneedling treatments over the face and neck. Investigators used high-resolution ultrasonography, optical coherence tomography, transepidermal water loss and BTC-2000 as well as 0.33mm microbiopsies to assess the efficacy of microneedling on facial and neck fine lines and wrinkles.

A total of 32 subjects (93.75% female, 6.25% male) completed all four session as well as a one-month and three-month follow-up. At three months post treatment, facial dermal and epidermal density increased an average of 101.86% and 19.28%, respectively, and facial elasticity increased 28.2% from baseline. Relative collagen type III and elastin gene expression was statistically higher three months post-treatment, but total elastin protein levels were unchanged compared to baseline. More than half (58%) of biopsies extracted three months post-treatment showed dermal muscle formation, compared to 15.3% at baseline.

The authors concluded that “The results illustrate the effects of microneedling treatments. Non-invasive measurements and biopsy data showed changes in skin architecture and collagen/elastin gene expression suggesting skin rejuvenation, with new extracellular matrix production and muscle formation.”

 

More in News