Young Pharmaceuticals, a product developer for dispensing dermatologists, has formulated a topical solution with soy isoflavones for estrogen-deficient skin, a common issue found in perimenopausal and menopausal skin: the RevEstro Balancing Night Cream.
John Kulesza, president and chief formulating officer of Young Pharmaceuticals, created the retinoid-free balm 
Young Pharmaceuticals
Kulesza says niacinamide, a form of vitamin B3, enhances barrier function for improved hydration, while vitamins C, E and ferulic acid ester combined with peptides support the production of structural proteins such as collagen and elastin.
“[The RevEstro also] combines soy isoflavones with a growth factor and barrier replenishing lipids to deeply hydrate and fortify the skin barrier,” Barnes explains.
Soy-derived phytoestrogens are naturally occurring nonsteroidal compounds derived from plants that resemble estrogen, according to an NLM study. Isoflavones are able to bind to estrogen receptors in the skin and help production.
“Age–especially perimenopause and menopause–can cause estrogen levels to decline,” says Kulesza. “Because estrogen is needed to maintain skin hydration, collagen and elastin, low levels can cause the skin to look older.”
Individuals start showing signs of estrogen-deficiency around the age of 47, Kulesza says. Studies have also shown that estrogen deficiency accelerates the loss of skin elasticity by triggering changes in elastin fibers, leading to wrinkles, according to NLM.
A recent study of 30 postmenopausal women receiving a treatment of 100 mg/day of an isoflavones soy extract for six months suggest the effectiveness of phytoestrogens in skin health. The study found a 9.46% increase in the thickness of the epidermis in 23 women, and the number of elastic fibers increased in 22 women.
