Exofecta combines exosomes, human stem cell growth factors, and copper peptides in a hyaluronic acid base to enhance skin recovery after procedures.
Courtesy of Factor Five
Exofecta is a topical containing hyaluronic acid and three other ingredients that give it its name, a trifecta, the researchers for this product say: exosomes, human stem cell growth factors and copper peptides. While these ingredients find their way into topicals separately, Factor Five combined these bioactives by using Dynamic Cultured Media for potency and a lyophilized two-part system to preserve the growth factors and exosomes. Designed for professionals to use for post-procedure recovery, the droplets are extracted using a needle-like syringe to draw the contents from the vial.
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Exofecta is a topical containing hyaluronic acid and three other ingredients that give it its name, a trifecta, the researchers for this product say: exosomes, human stem cell growth factors and copper peptides. While these ingredients find their way into topicals separately, Factor Five combined these bioactives by using Dynamic Cultured Media for potency and a lyophilized two-part system to preserve the growth factors and exosomes. Designed for professionals to use for post-procedure recovery, the droplets are extracted using a needle-like syringe to draw the contents from the vial.
The metered-dose lyobead system allows for consistent, measurable application of active ingredients, ensuring reliable results.Courtesy of Factor FiveThe topical, launched on June 2, is a metered-dose lyobead skincare product that essentially allows the developers to count out the number of liquid beads in a vial and determine a “dosage” of the growth factors, exosomes and copper peptides. This differs from powder-based products where discerning how much to use can be difficult, said licensed esthetician Tiffany Underwood, David Stachura, PhD and John Aylworth, PhD, the researchers behind this topical.
Exofecta’s human adipose stem cell-derived actives are produced in controlled conditions, they added, to ensure every treatment contains the same high concentration of growth factors and exosomes. The exosomes act like “messengers” delivering bioactive signals that are meant to trigger cellular repair, collagen remodeling and anti-inflammatory effects.
The addition of growth factors has been shown to aid in signaling fibroblasts, keratinocytes and endothelial cells to start repairing tissue, producing collagen and regenerating the “extracellular matrix.” “At the same time, they have been shown to calm inflammation, reducing redness and swelling, which shortens downtime and enhances comfort,” the researchers said.
Exofecta was designed to be used immediately post-procedure. It can be applied in-office right after microneedling, laser, RF or other treatments. Exofecta’s name was inspired by the fact that products that contain each of these three ingredients have its own benefits separately, but Factor Five wanted to develop a product with all three together—all dissolved into a sterile hyaluronic acid concentrate.
Studies indicate that human copper-binding peptide, a naturally occurring tri-peptide in human plasma that also can be released from tissues in case of an injury, can tighten loose skin and reverse thinning of aging skin, repair protective skin barrier proteins and improve skin firmness and elasticity [1].
“The result is a consistent, potent and a targeted regenerative response, which is especially beneficial after procedures where predictable recovery is critical,” the researchers said.
Exofecta’s ingredients and manufacturing processes comply with rigorous safety and quality standards, the researchers added. The first vial, a hyaluronic hydrator, is meant to hydrate and prep the skin for enhanced absorption. Vial E2, the exosome and growth factor lyobeads, comes in next with lyophilized exosomes and human stem cell growth factors for optimal potency to be absorbed into the skin, per a June 16 press release.
Ingredients (Vial E2 Exosome and Growth Factor LyoBeads): Human adipose exosome concentrate (created through patent-pending Dynamic Cultured Media process) human stem cell conditioned media, Bis (Tripeptide-1) Copper Acetate, Trehalose
