A placebo-controlled study evalualting the efficacy and safety of human adipocyte-derived mesenchymal stem cells-conditioned media (ADSC-CM) on patients who underwent nonablative fractional laser for the treatment of androgenetic alopecia (AGA) showed significant increases in hair density and volume.
Related: Topical ADSC Enhances Outcomes of Ablative Laser
For the study, published in Dermatologic Surgery (December 2020), Young In Lee, MD, et al, treated 30 AGA patients with nonablative fractional laser treatment and topically administered ADSC-CM or placebo solution.
The primary outcome of hair density was assessed using phototrichograms taken at each visit. The researchers used clinical digital photographs taken at the initial and final visits and assessed by two independent dermatologists to assess global improvement scores (GISs).
The ADSC-CM group had significantly higher final densities compared with the placebo group. The GIS of the ADSC-CM group was also significantly higher than the placebo group. No adverse effects associated with the application of ADSC-CM were noted during the study.
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