A comparative clinical and dermoscopic study of oral vitamin D alone, topical minoxidil or a combination of both in patients with female pattern hair loss (FPHL) found that combination therapy offers superior benefits to either treatment alone.
For the study, published in the Journal of Cosmetic Dermatology (January 10, 2022), Ghada F. R. Hassan, MD, evaluated the serum levels of 25-hydroxy vitamin D in patients with FPHL as well as the efficacy of the three treatment options.
A total of 60 subjects were enrolled (45 patients with FPHL and 15 controls) to measure serum levels of vitamin D. Subjects with FPHL then were subdivided into three groups: Group 1 received topical minoxidil and oral vitamin D, Group 2 received topical minoxidil and Group 3 received oral vitamin D for six months.
The investigators performed clinical and dermoscopic evaluation for all three groups before and after treatment.
They found that subjects with FPHL had significantly lower serum levels of vitamin D compared to controls. After treatment, there was statistically significant improvement in hair growth and thickness in Groups 1 and 2, but no significant improvement was found in Group 3. The combination treatment group had better results than topical minoxidil alone.