Developed in collaboration with 20 skin regeneration scientists, Skinceuticals created its Advanced RGN-6 after nearly five years of research. The regenerative topical was inspired by laser science, improving the skin’s quality and susceptibility to irritation post-laser–advancing treatment results and supporting aging skin. After seeing positive feedback with the initial rollout in physician offices, the product was released to consumers on May 1.
Designed to amplify the results of laser treatments, and also treat aging skin without the use of laser therapy, the RGN-6 cream features six active ingredients to minimize downtime and improve six key dimensions of visible skin damage: discoloration, redness, PIH, firmness, elasticity and smoothness.
Within the topical is 1% Eperuline, a plant-derived anti-inflammatory active that helps reduce redness and oxidative stress; 0.2% Ectoin, a protection molecule against environmental stressors, while also enhancing barrier function; 10% Glycorepair to help skin regeneration and 0.2% of Bioceramide–preventing transepidermal water loss.
The cream also contains 3% Acetyl Tetrapeptide-9, a biomimetic peptide that stimulates collagen, and 2% Niacinamide for skin brightening and hyperpigmentation reduction.
After laser therapy, the skin becomes more vulnerable as the procedure creates controlled micro-injuries or removes outer layers, disrupting the protective barrier. This makes the skin more sensitive to environmental factors like UV radiation, bacteria and irritants, hence the use of these ingredients.
During an April 22 webinar regarding the RGN-6 product, Corey Hartman, MD discussed a four-week clinical study conducted on 35 female subjects with Fitzpatrick type II and III, ages 30 to 65. The topical was applied twice daily following treatment of a non-ablative fractional laser. Laxity, Hartman said, improved at 20% post-laser and when in conjunction with the RGN-6, laxity improved by nearly 30% post-laser.
“Advanced RGN-6 unique active combination makes it a powerful repairing and rejuvenating solution,” Hartman said. “It was demonstrated through ex-vivo and in-vitro studies measuring improvement in six key types of markers related to skin regeneration, including surface re-epithelization, inflammation modulation and pro-collagen stimulation.”
Hartman stated that 94% of subjects reported the product being gentle on the skin, while 97% reported the skin feeling more comfortable post-laser. The product helps heal peeling skin, bruising, swelling and redness post-laser, and in 12-weeks, Advanced RGN-6 decreased redness by 69% in patients [1].
“In a clinical study on all skin tones, Advanced RGN-6 was shown to visibly reverse signs of aging and tone damage, like redness, post-acne marks, discoloration and wrinkles,” Hartman said.
References:
1- https://www.prnewswire.com/news-releases/skinceuticals-launches-advanced-rgn-6-regenerative-skincare-cream-inspired-by-laser-regeneration-science-302443350.html
