HA Filler Volbella Offers One Year Longevity for Infraorbital Hollowing

Three-dimensional imaging showed a mean volume increase from baseline of 0.733 mL (left) and 0.777 mL (right) at Month 12.

Subjects had increased undereye volume one year after treatment with Juvederm Volbella.
Subjects had increased undereye volume one year after treatment with Juvederm Volbella.

Juvederm Volbella is effective in correcting moderate-to-severe undereye hollowing with results lasting at least one year. Sabrina Fabi, MD, et al, performed a prospective, multicenter, single-blind, randomized, controlled study of VYC-15L (Juvederm Volbella) for correction of infraorbital hollowing (Aesthetic Surgery Journal, August 5, 2021).

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The primary endpoint was defined as the proportion of participants with ≥ 1-grade improvement at three months post-treatment, as assessed by an evaluating investigator (EI) using the Allergan Infraorbital Hollows Scale (AIHS). The researchers also performed three-dimensional imaging to assess infraorbital volume through 12 months post-treatment.

At three months, the difference between the treatment group (83.1%) and control (15.6%) was 67.5%. Three-dimensional imaging showed a mean volume increase from baseline of 0.733 mL (left) and 0.777 mL (right) at Month 12.

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The mean subject-reported pain scores were < 1.7 (scale of 0 to 10). Injection-site responses, which were mild/moderate and resolved in less than week, included tenderness (49.5%), bruising (42.7%) and swelling (41.7%).

Fourteen subjects (10.3%) had treatment-related adverse events, which resolved in less than two weeks and included bruising (3.8%) and swelling/edema (2.9%). Three participants had swelling/edema starting less than 30 days post-treatment; two cases resolved in less than four days and one by 45 days. No treatment-related serious adverse events were reported.

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The authors concluded that “VYC-15 was safe and effective for the correction of moderate or severe infraorbital hollowing and lasted through one year.”

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