In the evaluation of the effects of a series of laser treatments with very short, nanosecond pulses in the treatment of melasma on Caucasian women, researchers discovered that low-fluence 1,064 nm QSNY laser effectively provides long-term results in melasma treatment. Their findings were published in the Journal of Lasers in Surgery and Medicine (September 2021).
The study included 40 polish women with Fitzpatrick skin phototype II-III and melasma. Subjects received nine treatments with 1,064 nm Q-switched neodymium:yttrium-aluminum-garnet (QSNY) laser (pulse with 5 ns; spot size, 6-8 mm; fluence, 1.7-3.2J/cm2; 2-8 passes). The researchers evaluated the melanin index (MI) and erythema index (EI) using the Mexameter MX18 and the modified Melasma Area Severity Index (mMASI). The participants also self-assessed their treatment results, and 21 subjects returned for a 12 month follow-up.
The mean MI and mMASI scores showed significant improvement and reduction in melasma pigementation. EI reduction was also achieved. Of the participants, 70% rated the laser as a method that met their expectations for treating melasma. The one-year follow up showed that the reduced melasma effect was maintained, and patients also noted improvement in skin radiance, smoothness, brightness, hydration and regeneration.
With these results and no adverse effects being observed, researchers deemed low-fluence 1,064 nm QSNY laser as an effective, safe and noninvasive method for long-term melasma treatment results.