SVF Does Not Enhance Efficacy of PRP

The addition of stromal vascular fraction did not enhance skin quality outcomes.
The addition of stromal vascular fraction did not enhance skin quality outcomes.

Lipofilling with adipose-derived stromal cells (ASCs) has become popular as a treatment to improve aging-related skin characteristics, including wrinkles, pigmentation spots, pores and rosacea. But do additives such as platelet-rich plasma (PRP) or stromal vascular fraction (SVF) increase its therapeutic effect?

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This is the question researchers sought to answer with a study published in the August 2021 issue of the Aesthetic Surgery Journal (August 2021).

The prospective, double-blind, placebo-controlled, randomized trial was conducted between 2016 and 2019. A total of 28 female subjects received PRP-supplemented lipofilling with either mechanically isolated SVF, which was isolated by fractionation of adipose tissue (tSVF), or saline.

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The investigators assessed changes in skin elasticity and transepidermal water loss, changes in skin-aging-related features (i.e., superficial spots, wrinkles, skin texture, pores, vascularity and pigmentation), as well as patient satisfaction (FACE-Q), recovery and number of complications up to one-year postprocedure.

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The addition of tSVF did not improve skin elasticity, transepidermal water loss or skin-aging-related features. No improvement in patient satisfaction with overall facial appearance or facial skin quality was seen when tSVF was added to PRP-supplemented lipofilling.

The authors concluded that, while tSVF with lipofilling is a safe procedure, it does not improve facial skin quality in comparison to PRP-supplemented lipofilling.

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