A study published in Clinical, Cosmetic and Investigational Dermatology (August 2015) found that the sodium copper chlorophyllin complex contained in Phytochromatic MD Complex (MDRejuvena) has strong hyaluronidase inhibitory activity.
For the in vitro study, high-performance liquid chromatography and mass spectroscopy were used to analyze and identify the primary small molecule constituents in various old and new commercial lots of sodium copper chlorophyllin complex. Sodium copper chlorophyllin complex and copper isochlorin e4 disodium salt showed hyaluronidase inhibitory activity down to 10µg/mL, while oxidized copper isochlorin e4 disodium salt had hyaluronidase inhibitory activity at 100µg/mL but not at 10µg/mL.
“Inhibition of the breakdown of HA by sodium copper chlorophyllin is an important finding, as it may enhance HA levels in the skin. This activity may be one of the main activities responsible for the anti-aging effects of topical products containing copper chlorophyllin,” said dermatologist David B. Vasily, MD, of Aesthetica Cosmetic and Laser Center in Bethlehem, Pennsylvania.